FN3: A Promising Drug Target for Tissue Regeneration and Cancer
FN3: A Promising Drug Target for Tissue Regeneration and Cancer
Fibronectin Type III Domain (FN3) is a protein that is expressed in a variety of cell types, including connective tissue, muscle, and nerve cells. It is a member of the integrin family, which is a group of transmembrane proteins that play important roles in cell-cell and cell-extracellular matrix interactions.
One of the unique features of FN3 is its ability to interact with integrin alpha-2 (ITGA2), a protein that is also known as CD73. This interaction between FN3 and ITGA2 is critical for the regulation of cell-cell adhesion and for the development of tissues and organs.
In addition to its role in cell-cell interactions, FN3 is also involved in the regulation of cell-extracellular matrix (ECM) interactions. This is accomplished through the interaction of FN3 with ECM components such as collagen and elastin.
The FN3 protein has several unique features that make it an attractive drug target. First, it is a monomeric protein, which means that it consists of a single polypeptide chain. This makes it easy to design and develop small molecule inhibitors. Second, FN3 has a clear and well-defined binding site on ITGA2, which makes it easier to identify and modulate its activity.
FN3 has been shown to play a role in a variety of biological processes, including tissue repair, cell migration, and cell-cell adhesion. It is also involved in the regulation of cell-cell interactions, which are critical for the development and maintenance of tissues and organs.
In addition to its role in biology, FN3 is also a potential biomarker for a variety of diseases. For example, FN3 has been shown to be downregulated in a variety of cancer types, which suggests that it may be a useful target for cancer therapies. Additionally, FN3 has been shown to be involved in the regulation of tissue repair and regeneration, which makes it an attractive target for therapies that are designed to promote wound healing and tissue regeneration.
Overall, the FN3 protein is a unique and promising drug target. Its monomeric nature, clear binding site on ITGA2, and involvement in a variety of biological processes make it an attractive target for small molecule inhibitors. Additionally, its potential as a biomarker for a variety of diseases makes it an important area of research for the development of new therapies.
Protein Name: Fibronectin Type III Domain (nonspecified Subtype)
The "Fibronectin Type III Domain Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about Fibronectin Type III Domain comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
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